Letter from Linus Pauling to J.B.S. Haldane. August 16, 1955. Page 1  Larger Images / More Information. 1 p.  View Transcript

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Activity Listings

• Check from LP to Linda Pauling for $300.00. [Filed under LP Biographical: (Business and Financial: Bank Statements and Canceled Checks, February 1956-December 1957), Box #4.024, Folder #24.1] [Also filed under LP Biographical: (Business and Financial: Check Registers, 1951-1960), Box #4.075, Folder #75.3]
• Counter Receipt for Southern Commercial and Savings Bank to LP to $200.00. [Filed under LP Biographical: (Business and Financial: Bank Statements and Canceled Checks, December 1954-February 1956), Box #4.023, Folder #23.1]
• LP Notes: Summary of an article by R. Aschaffenburg and J. Drewry, "Occurrence of Different β-Lactoglobulins in Cow's Milk" in relation to his manuscript, "A Molecular Theory of General Anesthesia." [Manuscripts, Typescripts, and Notes 1961] [Filed under LP Manuscripts of Articles: (Manuscripts and Typescripts of Articles by LP, 1961), Box #1961a3, Folder #1961a3.3]
• Letter from Charles M. Carpenter, M.D., Chairman, Research Advisory Committee, City of Hope Medical Center, to LP RE: Announces the Research Advisory Committee's first meeting of the 1955-56 year. Gives details of the meeting's agenda. Requests that enclosed RSVP card be returned. [Filed under LP Correspondence: (C: Organizational Correspondence. (Ch - Ci)), #70.9]
• Letter from Dr. B. Mukerji, Central Drug Research Institute, Chattar Manzil Palace, India, RE: Thanks LP for extending an invitation for Dr. M. L. Dhar to work at Caltech, carrying on research in chemistry in relation to medicine. Would be grateful if LP would look into a grant from the Rockefeller Foundation as he suggested, for at the moment, the Indian government will not support this research. Remembers LP and AHP's visit with pleasure. LP's lectures were deeply appreciated. [Letter from LP to Mukerji August 4, 1955] [Filed under LP Correspondence: (M: Correspondence, 1950-1955), #256.6]
• Letter from Dr. W. Foerst, Heidelberg, Germany, to LP RE: Written in German. [Filed under LP Books: (General Chemistry: An Introduction to Descriptive Chemistry and Modern Chemical Theory, Second Edition), #1953b.2]
• Letter from LP to C. David Gutsche, Washington University RE: LP will not be able to make it to St. Louis. [Letter from Gutsche to LP June 28, 1955] [Filed under LP Science: (John Simon Guggenheim Memorial Foundation, 1953-1975), Box #14.015, Folder #15.3]
• Letter from LP to Dr. N. V. Bhaduri, Calcutta School of Tropical Medicine, India, RE: Dr. Itano and LP have prepared their manuscript on abnormal hemoglobin. It exceeds Bhaduri's journal's length limit. Thus, Itano and LP have decided to have it published in the Journal of the Swedish Chemical Society. [Filed under LP Correspondence: (B: Correspondence, 1955-1957), #38.1]
• Letter from LP to Dr. Roy J. Kuffner, Fisk University, RE: Agrees that Hollingsworth had already in 1952 discussed the phase rule in a way exactly similar to that advanced by Professor Schomaker. Finds the discussion in Hollingsworth's article to be almost identical with Schomaker's ideas. [Letter from Kuffner to LP June 27, 1955] [Filed under LP Correspondence: (K: Correspondence, 1936-1956), #200.20]
• Letter from LP to Dr. Vikram A. Sarabhai, Physical Research Laboratory, Navrangpura Ahmedabad, India, RE: Pleased that Sarabhai will be visiting on September 2. LP and AHP look forward to seeing him. Has asked Neher and Anderson if Sarabhai can join LP and AHP at 3 PM. LP will see that Sarabhai gets to the airport or hotel. Invites Sarabhai to spend the night at LP and AHP's home. [Memo from LP to Anderson and Neher August 18, 1955] [Filed under LP Correspondence: (S: Correspondence, 1953-1956), #379.3]
• Letter from Mary Frances Chadderdon, Long Beach Liberal Forum Committee, The Unitarian Church, to LP RE: The Long Beach Liberal Forum invites LP to speak at the opening program of its fall season. The audience would be around 100-200 people, comprised of many college professors, professionals, and educators. LP could speak on a topic of his choice. Willing to provide $50 to cover any expenses. Suggests possible dates in October, January or February. [Letter from LP to Chadderdon August 25, 1955] [Filed under LP Correspondence: (C: Correspondence, 1921-1957), #74.23]
• Memo from LP to Professor Carl Anderson and Professor Victor Neher RE: Suggests that Dr. Vikram A. Sarabhai be turned over to LP at 3 PM on September 2. LP would arrange to get Sarabhai to the airport or hotel. [Letter from Sarabhai to LP August 13, 1955, Letter from LP to Sarabhai August 18, 1955] [Filed under LP Correspondence: (S: Correspondence, 1953-1956), #379.3]
• Memorandum: LP to Dr. Makio Murayama. [Filed under LP Science: Box #6.007, Folder #7.8]

  California Institute of Technology Inter-Office Memo

  To Dr. Murayama From Linus Pauling Date 18 August 1955

  Subject Proposed Research on Human Hemoglobin

  H. G. Kunkel and G. Wallenius, Science 122, 288 (1955), have reported finding a new hemoglobin in normal adult human blood. This hemoglobin when subjected to electrophoresis in a starch slab, barbital buffer of pH 8.6, migrates less than half as fast as A. Under these conditions it migrates equivalently to E. They report a range of 1.8-3.5% of this hemoglobin, relative to A, in individuals with various chronic diseases.

  In addition, they report that normal adult blood shows small amounts of hemoglobin migrating more rapidly than A.

  They have isolated part of these hemoglobins (the rapid one is supposed to be heterogeneous).

  I think that it is possible that these new hemoglobins represent errors in polypeptide-chain synthesis by the normal gene. I propose that we investigate them with this in mind. Perhaps only the more rapid hemoglobin is of this type.

  I suggest that as a first step you repeat some of the work of Kunkel and Wallenius. I propose then to get blood from patients in Pacific State Hospital, in order that the amounts of the new hemoglobins can be determined.

  I think that you should isolate some of the new hemoglobins, and we might ask Dr. Rhinesmith to investigate their end groups. It may be worth while to try to so a better job of fractionation of the faster component than was done by Kunkel and Wallenius.

  Linus Pauling:L