Activity Listings
- Entry in Calendar: “Linda leaves on Daylight. HICCASP Meeting” [Filed under LP's Daily Calendar of Events, 1946, 1958-1966, 1968-1970, 1973-1979: Box #5.012, Folder 12.1]
- Letter from Chauncey D. Leake to LP RE: Congratulates LP on winning the Willard Gibbs Medal. [Filed under: LP Speeches, 1946s.8]
- Letter from LP to A. Rauch, Development Department, Walter Kidde and Company. RE: Informs him that Dr. Beckman is in charge of manufacturing the instrument. Gives contact information. [Letter from Rauch to LP June 18, 1946] [Filed under LP Science: Scientific War Work - Materials re: the Pauling Oxygen Meter, 1940-1947: Box #13.001 Folder #1.2]
- Letter from LP to Dr. A. L. Patterson, Department of Physics, Bryn Mawr College RE: States that he will be very glad to see Patterson and his wife. Also informs that Corey and Sturdivant will be available at that time, as well as Beadle and his men. Requests that Patterson give a short talk before a small group of students on the problem of ambiguities if time allows. [Letter from Patterson to LP June 26, 1946, July 8, 1946] [Filed under LP Correspondence: Box #304.8, file: (Patterson, A. L.)]
- Letter from LP to Frank Aydelotte RE: Thanks him for his letter about the appointment as Eastman Professor for 1947-1948, as well as his congratulations on the Willard Orbis medal and the letter Aydelotte sent to Arveson. Agrees to the plan to sell the Eastman House and find other lodging, mentioning that Ava Helen and the children are quite excited about the coming year. Also asks if he should write the chemists at Oxford to inquire about the types of lectures he should give while there. [Letter from Aydelotte to LP July 11, 1946] [Filed under LP Correspondence: Box #6.21, file:(Aydelotte, Frank, 1940-1956) and copy in #299.8 (Oxford University, [re: Eastman professorship and residency in Oxford] 1946-1948)]
- Letter from Linus Pauling to Arthur Pardee. [Filed under: RNB 17R: Addendum]
July 2, 1946
Mr. Arthur Pardee
Linus Pauling
Proposed Research on Gout
Would you like to work this summer on a problem in which I am interested? This relates to the use of colchicine as a specific for gout.
I do not know whether or not there is any information in the literature about specific combination of colchicine and uric acid. I would suggest that it might be interesting to determine the solubility of uric acid or sodium urate in aqueous solutions of colchicine, and to determine whether or not the colchicine forms a complex with uric acid. Colchicine is very soluble in water. The solubility of uric acid in cold water is one part in 15000 and of mono sodium urate one part in 1200.
Cinchophen seems also to increase the excretion of uric acid and diminish its concentration in the blood, and it is used in the treatment of gout. I think that it would be worth while to make a similar study of the complex formation of cinchophen and uric acid.
Both colchicine and cinchophen are poisonous. Perhaps a study of the effect of various substances on the solubility of uric acid or sodium urate would lead to the discovery of a non-poisonous substance which would be useful in the treatment of gout.
- Letter from W. A. Noyes, Jr., Editor, Chemical Reviews to LP RE: Requests he review an article, “Atomic Orientation and Electron Distribution” for publication. (Notes in pencil in bottom margin: “Dr. Ethinger - Would you give me your opinion? LP” “Title not well chosen ‘Steric Inhibition of Resonance'”) [Letter from LP to Noyes August 13, 1946] [Filed under LP Correspondence Box #70.5, file:(Chemical Reviews, 1936-1937, 1940, 1949-1951)]
- Writes cheque to “Dunnings,” $10.20 [LP Biographical: Business and Financial 4.073, folder 73.4]
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July
2, 1946
