May 3, 1943
Dr. T. Addis
Stanford University
School of Medicine
2398 Sacramento Street
San Francisco, California
Dear Tom:
I was very glad to see your two letters when I got back from the East on Friday.
A week ago Friday I had a good visit with Dr. Robert Loeb, whom I had not met before. He talked to me a long time about the blood substitute situation. He told me that so much human plasma is being collected that the C.M.R. now feels that the blood substitute problem is no longer so urgent as it was a year ago. Moreover, the unsatisfactory outcome of the bovine albumin project has discouraged the blood substitute group somewhat. Nevertheless, his committee will, I think, support some blood substitute work, such as that which we are carrying on.
I am glad to learn that you are now getting more promising results with pectin than before.
Why do you not write to Loeb and submit to him your suggestion regarding the possible use of human globin? It seems to me that this idea might well be worth some preliminary work. I suppose that there is some danger that the process of removal of the hemes would alter the globin in such a way as to produce toxic reactions, but this could be answered only be experiment.
We are going to start out now to prepare a large amount of our polyoxy gelatin, and to give it as complete characterization by physical-chemical methods as possible, before submitting it to physiologists. I hope that we shall have some ready for you before many months have gone by.
Dr. Koepfli told me that you had composed a fine letter to the C.M.R., advocating that more technical aides be hired and that other similar measures be adopted to improve the efficiency of the Committee. He said that he had obtained several signatures for the letter down here. I am glad that you have gone ahead with this work, along these lines. Robert Loeb told me that he had difficulty in keeping up with his C.M.R. duties, because he does not have any technical assistance. I think that he should have a technical aide.
We were all happy to have you and Mrs. Addis here, and I hope to see you again before long.
Sincerely yours,
Linus Pauling
LP/pp