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- Photo: Crellin Pauling celebrating New Year's Day by wearing a paper hat and blowing a noise-maker. “Crellin Pauling celebrating New Years Day 1941 Age 3 ½ years” “Neg made. 325 0821” Photographer unknown. Black and white print. [Ship #3761] [Filed under LP Photo Box: 1941i.40]
- Photo: Linda, Crellin, and Peter standing outside their house, blowing noise makers and wearing party hats. “Linda, Crellin, Peter January 1,1941.” Photographer unknown. Black and white print. [Ship #634] [Filed under LP Photo Box: 1941i.1]
- Photo: Linda, Peter, and Crellin blowing noise makers, standing on a driveway in front of the house. “Linda 8 ½, Peter 10 e.g. 9 11/12, Crellin 3 ½, January 1, 1941.” Photographer unknown. Black and white print. [Ship #636] [Filed under LP Photo Box: 1941i.3]
- Photo: Peter and Linda Pauling outside, walking away from the camera and towards their house. Both blowing noise makers and wearing party hats. Photographed from the back. “Peter and Linda, January 1, 1941.” Photographer unknown. Black and white print. [Ship #635] [Filed under LP Photo Box: 1941i.2]
- Letter from Fred Allen to LP RE: Informs him of details for the next meetings of the Purdue section of the A.C.S. Goes on to mention that Dr. Estey would like to know if LP would give a talk on the Chemical Aspects of Defense for a more general audience while he is in West Lafayette. [Filed under LP Correspondence: Box #5.2, file:(Allen, Fred 1941-1949)]
- Letter from LP to Dr. Warren Weaver, The Rockefeller Foundation. [Weaver's reply to LP July 14, 1941] [Filed under LP Science: Rockefeller Foundation, 1936-1948: Box #14.038 Folder #38.9]
January 2, 1941
Dr. Warren Weaver
The Rockefeller Foundation
49 West 49th Street
New York, New York
Dear Warren:
I am writing now to ask your advice about our research program in immunology.
First let me say that the work in organic chemistry and structural chemistry is going along well. Zechmeister, with two post-doctorate assistants and four graduate students, is making headway on several problems. He has fitted into our department satisfactorily, and there has been no trouble at all of the sort that sometimes accompanies the appointment of a European professor. Carl Niemann is working as hard as ever and as effectively. The molecular structure program is booming along. The crystal structure of alanine, now completed, has turned out to be especially interesting. In this crystal for the first time the positions of hydrogen atoms were verified by the x-ray data. We are now beginning to get good x-ray photographs of large polypeptides, with fifty or one hundred amino acid residues per molecule, and I think that we shall succeed in making complete structure determinations of these. At present we are studying polyglycines, and Dr. Edsall, who is here this year as Guggenheim Fellow, is now preparing some polypeptides containing both glycine and alanine. I am confident that this method of attack, using synthetic polypeptides of known amino acid composition, which might be called artificial proteins, will lead ultimately to the solution of the protein problem.
For about six months Dr. Dan Campbell, Rockefeller Fellow, and Dr. David Pressman have been working with me on experimental problems in immunology. This work has moved along slowly, because of its nature, but I am pleased with the results obtained. It was fortunate for us that Dr. Campbell was here. Dr. Pressman, an organic chemist trained here, was supported in part from the Rockefeller Foundation and in part from the Noyes Fund of the Institute. All together we have used about $2000 of this year's Rockefeller budget for the work in immunology. The researches completed or under way are the following.
1. Serological reactions with simple substances containing two or more haptenic groups. We have shown, verifying the work of Landsteiner and van der Scheer, that simple substances containing two or more haptenic groups will give the precipitin reaction with homologous antiserum and produce shock in sensitized guinea pigs. Hooker and Boyd had said that they could not obtain reactions of this type. We have made quantitative studies of the precipitin reaction, determining the amount of antibody nitrogen precipitated by the micro-Kjeldahl method. So far we have positive results for six substances involving arsanilic acid residues attached to resorcinol or phloroglucinol. These results are described in a paper which Campbell, Pressman, and I have published in the Proceedings of the National Academy of Science. The production of a precipitate by simple substances containing two or more groups is, I think, a very strong argument for the framework theory of antibody-antigen precipitates.
2. The manufacture of antibodies in vitro from normal serum proteins. In my paper I suggested that it should be possible to manufacture antibodies in vitro by denaturing serum proteins and slowly renaturing them in the presence of antigen. Experiments along these lines have been carried out, using three different fractions of beef globulin and the dye methyl blue as antigen. It was found that after denaturation of the protein with alkali or by heat slow renaturation in the presence of the dye produced a protein solution which combined with the dye much more strongly than protein solutions obtained in other ways, such as by rapid renaturation in presence of dye or by various treatments in absence of dye. Similar experiments were started here with bacteria as antigen, and Dr. Campbell plans to continue them in Chicago. Further work is needed to test the specificity of the artificially produced antigens, but the results obtained already are positive.
3. A quantitative study of sera homologous to antigens containing two different haptenic groups. Landsteiner reported experiments suggesting that no antibody molecules of type A'-B' were present in the serum produced by antigens containing two different groups A and B. This result is incompatible with my theory or any theory involving bivalent or multivalent antibody molecules. With the cooperation of Dr. Landsteiner, we have been carrying out quantitative studies of his sera, and have obtained results which support the conclusion opposite to that reached by him.
4. The theory that agglutination is the result of the clasping together of cells by bivalent antibody molecules requires that inhibition of agglutination occur on treatment of cells by a sufficiently strong agglutinin solution. Hooker and Boyd have reported failure to produce agglutination in erythrocytes and argue accordingly against the bivalent antibody theory. We are carrying out agglutination experiments using antiarsanilic acid serum as agglutinin and erythrocytes treated with diazotized arsanilic acid as the cells.
There are many other experiments which we plan to carry out. These include the quantitative study of antibody-antigen composition of precipitates, the determination of equilibrium constants and heats of reactions by physical-chemical methods, especially by the use of various haptens for the study of soluble complexes, the separation of antibodies of different kinds by combination with charged haptens and subsequent electrophoresis, the investigation of the order of the reaction of antibody production by quantitative studies of serum titer for large numbers of rabbits immunized by different amounts of antigen, etc. We are handicapped at present by our inability to determine the amounts of antigens, especially those containing arsenic, in small precipitates with sufficient accuracy. This problem can be solved easily by the use of radioactive arsenic (the isotope As74 made from germanium by deuteron bombardment, with sixteen-day half life), and Edwin McMillan has arranged for this to be made for us in Berkeley when we are in a position to use it effectively.
I feel enthusiastic about the program of research in immunology, and I would like to carry it on vigorously for some time in the future. In addition to the experiments mentioned above, we have many others under consideration, some of which have been suggested by the immunologists who have written to me since the appearance of my paper. I have, in fact, been carrying on a rather lively correspondence with immunologists of the country, especially with Dr. Boyd in Boston, who is strongly opposed to my theory in so far as it involves bivalent antibodies. I find that immunological work is laborious, and that it moves along slowly unless a suitable number of assistants are available. I am afraid that it would not be possible to take from our present funds enough money to permit the work to be done effectively— we got along this year because of our accidental good fortune in having Dan Campbell here.
The program which I have in mind would involve the expenditure of about $20,000 per year, with the following budget:
Research Fellow, Immunology $3000.00
Research Fellow, Organic Chemistry 2400.00
Research Fellow, Physical Chemistry 2000.00
Assistant, Immunology 1500.00
Assistant, Organic Chemistry 1200.00
Assistant, Microanalysis and Radioactivity 1400.00
Apparatus, supplies, animals 7500.00
Expenses of visiting professor 1000.00
Total $20,000.00
As Research Fellow in Immunology I would like to have Dr. Dan Campbell, at present Assistant Professor of Bacteriology and Immunology at the University of Chicago. He is a good technician in the field, an industrious man who works steadily day after day, and a man with interest in chemistry and with an open mind regarding science. I doubt that a better man could be found for this appointment. As Research Fellow in Organic Chemistry I would suggest Dr. David Pressman, who has been carrying on this work this year, and has become deeply interested in immunology. He has been helped in the preparation of organic substances this year by two seniors in chemistry, the two best men in our senior class. Both are American-born Japanese. I think that one might be kept on next year full time as assistant in organic chemistry. The item of $7500.00 for apparatus, supplies, animals would permit us to use the large number of animals required for some of our projected researches, and should permit also the construction of a Tiselius apparatus for the electrophoretic separation of antibody fractions by the suggested method of combination with charged haptens, and for other investigations. I have included the item $1000.00 for expenses of a visiting professor. It seems to me that one of the best ways of assuring that we were making an effective attack on immunological problems would be to bring here each year some authority in the field, for discussion and collaboration. This would be of value also to the people here in biology.
I would like to be able to plan to carry on this program over a five-year period.
Would you please tell me whether you think that it would be worth while for an application along these lines to be submitted to the Rockefeller Foundation and if so in what respects the application should deviate from the outline given in this letter. I would like our attack on the problem to be intensive enough to be effective, and the program which I have described above is, I think, just about right.
With best regards, I am
Sincerely yours,
Linus Pauling
LP:jr
- Letter from Richard H. Wilhelm, Princeton Section, American Chemical Society, to LP. RE: Delighted that he is able to visit. Has tentatively scheduled the symposium for March 5 and 6. [Filed under LP Science: American Chemical Society: Correspondence, 1925-1942: Box #14.002 Folder #2.5]
- Letter from W.J. Gartner, Production, McGraw-Hill Book Company Inc., to LP. RE: Asking him to review the proof of corrections that were being sent to him before they started the reprint. [Filed under: LP Manuscripts of Books, 1935b.1]
- Letter from Dr. R. Bowling Barnes to LP RE: Asks LP if he will be in Pasadena during late January and early February. Hopes to visit the laboratory and recruit men for positions at his lab. [Letter from LP to Barnes January 10, 1941] [Filed under LP Correspondence: Box #37.8, file:(B: Correspondence, 1941)]
- Letter from Prof. H. I. Schlesinger, Dept. of Chemistry, University of Chicago, to LP RE: Suggests a schedule for when each lecture will be given when LP teaches at the University of Chicago next summer. Asks LP what the course catalog should list as a prerequisite and for short descriptions of each of the courses. Asks some questions on his personal work regarding the chemical structure of metallic borohydrides. [Letters from LP to Prof. H. I. Schlesinger December 27, 1940, January 7, 1941] [Filed under LP Correspondence: #357.7]
- Letter from Dr. Leslie Bliss to LP RE: Thanks him for the paper sample tests and asks him about the travel allowance policy of an organization for purposes of comparing those at his institution. [Letter from LP to Bliss January 7, 1941] [Filed under LP Correspondence: Box #37.8, file:(B: Correspondence, 1941)]
- Letter from LP to Fred Allen RE: Regrets that he will not make it to Purdue this Spring. Notes that he will begin giving the freshman lectures at Cal Tech next week. [Filed under LP Correspondence: Box #5.2, file:(Allen, Fred 1941-49)]
- Letter from LP to Roger Lescohier RE: Writes he has given Lescohier's letter to the Dean of the Graduate School who will send him a catalogue. Discusses national defense courses to be given at Cal Tech. [Filed under LP Correspondence: Box #230.7, file:(L: Correspondence, 1941)]
- Letter from LP to William McPherson, Department of Chemistry, Ohio State University, RE: Recommends to him Prof. Thorfin Hogness as a potential candidate to replace Dr. William Lloyd Evans as chair of the department after his retirement. [Letter from McPherson to LP December 30, 1940] [Filed under LP Correspondence: Box #162.5, file:(Hogness, Thorfin)]
- Letter from unknown (unsigned) to Bessie Little, RE: encloses a letter from Mr. Shippey and membership dues. Also gives updates on membership status of several people. [Filed under AHP: Federal Union, Pasadena Chapter: Box # 5.006, Folder 6.5]
- Letter from George B. Moffat to Whoever may be interested, RE: suggests that immediate action be taken to promote the Union idea due the recent occurrences in the war. [Filed under AHP: Federal Union, Pasadena Chapter: Box # 5.007, Folder 7.4]
- Letter from T. K. Sherwood, National Defense Research Committee, to LP. Is curious to find out what LP has found on the shock of hydrogen peroxide. Requests a report on the oxygen indicator. [Letter from Chadwell November 29, 1940, Letter from LP to Sherwood, January 10, 1941] [Filed under LP Science: Scientific War Work - Materials re: the Pauling Oxygen Meter, 1940-1947: Box #13.001 File1.1]
- Research Notebook of LP, RNB 19R, p. 3 RE: Rate of Reaction of 2 Fe+++ + Sn++ → 2Fe++ + Sn++++.
- Federal Union Inc. Headquarters Bulletin No 9. Union Now Marches On. [Filed under Publications re: Union Now/Federal Union, Inc., 1940-1941: Box # 5.009, Folder 9.6]
- Letter from LP to Dr. Leslie Bliss RE: Informs him of the travel allowances provided by the Federal Government and the Guggenheim Foundation. [Letter from Bliss to LP January 4, 1941] [Filed under LP Correspondence: Box #37.8, file:(B: Correspondence, 1941)]
- Letter from LP to Erle Billings RE: Sends names of the students who have not yet received national defense questionnaires. [Field under LP Correspondence: Box #37.8, file:(B: Correspondence, 1940)]
- Letter from LP to Prof. H. I. Schlesinger, Dept. of Chemistry, University of Chicago, RE: Agrees to the schedule of lectures proposed by Schlesinger and gives the titles and descriptions of the two courses. States he is uncomfortable with the structure of the diborane molecule Schlesinger described in the past letter. [Letters from H. I. Schlesinger to LP January 3, 1941, January 20, 1941] [Filed under LP Correspondence: #357.7]
- Note from Dr. Max Delbrück to LP. [Letter from LP to Delbrück January 20, 1940] [Filed under LP Correspondence Box: #92.1, file:(Delbrück, Max, 1940-1941)]
Jan 7, 1941
Dear Pauling,
I had a letter from Jordan, from Nov. 13. He is in the army since the beginning of the war, and his forwarding address is: c/o Pastor Finke, Rolandstrasse 9, Bremen. Probably he is now busy quenching? the fires. He would like to have a reprint of your antibody paper. Apparently he cannot send any of his papers, because there seems to be a prohibition on sending printed matter out of Germany. Apparently he does not feel very much [?] by our note in Science, because he says he does not believe in the resonance idea very much any how
You showed no reaction to the Frank-Kamenetzky proposal of synthesis by resonance between the reaction product and an intermediate activated state. I was X-mas in Princeton and talked it over with Wigner who saw no serious objection to it. One could probably test it by experiment without to much difficulty.
April 4 and 5 we are going to have a meeting here of the Southeastern Phycists, nothing to brag about. But we are trying to pep it up by a symposium on molecular structure, with Miss Sponer, Teller, H. H. Nieben, Brockway And Placzek. If an Eastern trip of yours would coincide with this date you would be most enthusiastically welcome to participate.
With best regards,
Max
- Postcard from J. Bernstein to LP RE: Requests reprints. (Note in pen: Sent 1/21/41 BRC) [Filed under LP Correspondence: Box #37.8, file:(B: Correspondence, 1941)]
- Research Notebook of LP, RNB 19R, p. 5 RE: Rate of Reaction of S2O8-- and 2I- → 2SO4– + I2.
- Writes cheque to "Southern Pacific R.R. Co.," $ 29.18. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Letter from Alpheus W. Smith, Dean of the Graduate School, Ohio State University, to LP RE: Thanks him for the letter recommending Prof. Hogness for the position of Chair in the Department of Chemistry. [Letter from LP to Smith December 30, 1940] [Filed under LP Correspondence: Box #162.5, file:(Hogness, Thorfin)]
- Letter from William McPherson, Department of Chemistry, Ohio State University, to LP RE: Thanks him for his suggestions. Mentions Dean Smith's trip to California.. [Filed under LP Correspondence: Box #255.8, file:(M: Correspondence, 1941)]
- Writes cheque to "Am. Ass. Univ. Professors," $4.00. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "Am. Phys. Soc." $9.00. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "Cal. Inst. Tech." $12.88. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "First Federal Savings and Loan Co.," $210.24. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "Frank Aisawa," $28.00. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "Mr. E.W. Crellin," $80.00. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "William and Wilkins Co.," $7.00. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to “AA Univ Prof. Dues” $4.00 [LP Biographical: Business and Financial 4.072, folder 72.3]
- Writes cheque to “Am Phys Soc & Chem Phys” $9.00 [LP Biographical: Business and Financial 4.072, folder 72.3]
- Writes cheque to “CIT B1 -10g.” $12.88 [LP Biographical: Business and Financial 4.072, folder 72.3]
- Writes cheque to “Chem Rev” $7.00 [LP Biographical: Business and Financial 4.072, folder 72.3]
- Writes cheque to “First Federal. Jan 1 payment” $210.24 [LP Biographical: Business and Financial 4.072, folder 72.3]
- Writes cheque to “Frank Aisawa. Gardening” $28.00 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Writes cheque to “Mr. EW Crellin. Jan 1 payment” $80.00 [LP Biographical: Business and Financial 4.072, folder 72.3]
- Inter-department communication from Dean Hinrichs to LP RE: Sends a personal recommendation for Miss June Haldy, who is applying to work as a secretary for LP. [Filed under LP Correspondence: Box #165.6, file:(H: Correspondence, 1941)]
- Letter from LP to Carl Niemann RE: Asks Mr. Niemann if he would be willing to accept responsibility for making assignments of teaching and assisting work of the organic assistants and fellows. [Filed under California Institute of Technology: Materials re: Division of Chemistry and Chemical Engineering, 1933-1963, No Date: Box #1.024, Folder 24.9]
- Letter from LP to Dan Campbell RE: Sends him a copy of their manuscript which is being submitted to the Proceedings of the National Academy. Updates him on news from the labs. [Filed under LP Correspondence: Box #57.6, file:(Campbell, Dan H., 1939, 1941, 1944, 1948-1949, 1956, 1961-1962, 1965, 1970, 1974)]
- Letter from LP to Professor E. B. Wilson, Harvard School of Public Health RE: Submits the enclosed manuscript “Serological Reactions with Simple Substances Containing Two or More Haptenic Groups” for publication in the Proceedings of the National Academy of Sciences. [Filed under LP Correspondence: 438.4]
- Letter from LP to William Boyd. [Letter from Boyd to LP December 29, 1940] [Filed under LP Correspondence: Box #29.3, file:(Boyd, William C., 1939-1945, 1956-1960)]
January 9, 1941
Professor William C. Boyd
Department of Biochemistry
Boston University
School of Medicine
80 E. Concord Street
Boston, Massachusetts
Dear Professor Boyd:
I am enclosing a copy of our manuscript on serological reactions with simple substances, and I would be glad to have your comments on it. We have included mention of the substances referred to in your letter, rather than only the substance referred to in the published discussion of your work. Is this satisfactory to you?
Dr. Pressman has pointed out to me that it is easier to attach azo groups in the 4.5 positions of dihydroxynaphthalene than the 2.7 positions. Have I interpreted your formula correctly as the 2.7 derivative?
I don't think that there can be misunderstanding about the question of composition of precipitate versus final concentration of reagents when the discussion is detailed enough to be understood. If equilibrium is reached, the composition of the precipitate must be determined by the final composition of the solution. If equilibrium is not reached, this need not be so.
I do not feel that the lattice theory is necessarily right - that is I am willing to be convinced by the evidence, although I recognize that it is going to be difficult to find a crucial experiment. It seems to me that the available information tends to support the theory rather than to discredit it. For example, I have felt on reading your papers on agglutination that you usually observed separate agglutination of different cells, and observed clumping together only when conditions were just right. This would be expected from the framework theory. How do you explain the formation of separate clumps under various conditions?
Sincerely yours,
[Linus Pauling]
LP: jr
- Note from Gustav Albrecht to LP RE: Asks him for advice on draft deferment as LP is on the National Defense Advisory Board, mentioning that he is a Class I despite being employed at Cummock School and continuing research at UCLA. [Filed under LP Correspondence: Box #4.1, file:(Albrecht, Gustav 1939-1964)]
- Letter from A. A. Scullin, Technical and Research Div., The Texas Co., to LP RE: States that Dr. L. R. Zumwalt is applying to their company and has given LP as a reference. Asks for LP's opinion on Zumwalt and any other pertinent information about his abilities. [Letter from LP to Mr. A. A. Scullin January 16, 1941] [Filed under LP Correspondence: (S: Correspondence, 1941), #377.11]
- Letter from Dr. A. M. Pappenheimer, Jr., Department of Bacteriology, University of Pennsylvania, to LP RE: Writes to inquire about a letter and manuscript he sent to LP for comment two months ago. [Letters from Pappenheimer to LP November 5, 1940, from LP to Pappenheimer January 23, 1941] [Filed under LP Correspondence: Box #312.6, file:(P: Correspondence, 1941)]
- Letter from LP to Dr. R. Bowling Barnes RE: Informs Barnes of his schedule so that he knows when best to come to Cal Tech. Recommends Dr. Zumwalt for work correlating infrared and Raman results. [Letter from Barnes to LP January 3, 1941] [Filed under LP Correspondence: Box #37.8, file:(B: Correspondence, 1928-1954)]
- Letter from LP to Dr. T. K. Sherwood, National Defense Research Committee. RE: Gives a report on the progress of the oxygen indicator. Hopes the indicator will be ready in one month. [Letter from Sherwood to LP January 6, 1941, Letter from Sherwood to LP January 17, 1941] [Filed under LP Science: Scientific War Work - Materials re: the Pauling Oxygen Meter, 1940-1947: Box #13.001 Folder #1.1]
- Letter from LP to Gustav Albrecht RE: Suggests that he have his research director at U.C.L.A. write a letter to the Draft board on his behalf. [Filed under LP Correspondence: Box #4.1, file:(Albrecht, Gustav 1939-1964)]
- Note from William Seifriz, Botanical Laboratory, University of Pennsylvania, to LP RE: Discusses the outcome of the protoplasm symposium and asks LP to write the introduction to the published symposium, or if he can use LP's book to help him write the introduction. [Letter from LP to Dr. William Seifriz January 20, 1941] [Filed under LP Correspondence: #361.5]
- Research Notebook of LP, RNB 19R, p. 9 RE: Decomposition of H2O2 and Test for H2O2.
- Letter from Charles D. Russell, Dept. of Chemistry, Duke University, to LP RE: States he has listed LP as a reference on two job applications and that he is looking for work in the field of National Defense. Describes his current work and education, and thanks LP for the reprints. [Letter from LP to Mr. Charles D. Russell January 16, 1941] [Filed under LP Correspondence: #340.6]
- Letter from LP to Prof. W. Albert Noyes, Jr., Department of Chemistry, University of Rochester, RE: States that they look forward to seeing him on January 24th. [Filed under LP Correspondence: Box #279.5, file:(Noyes, W. A., Jr.)]
- Letter from unknown (unsigned) to Bessie Little, RE: encloses associate membership cards for several people. [Filed under AHP: Federal Union, Pasadena Chapter: Box # 5.006, Folder 6.5]
- Note from Dr. James LuValle, Department of Chemistry, Fisk University, RE: Discusses the situation at Fisk, commenting on the lack of apparatus in the physical chemistry department and the pay cuts staff are being asked to take due to a budget crisis. Asks LP to help him find another position. Regrets that it may be difficult for him to be hired at many universities or firms as he is black. Also requests permission to use LP as a reference. [Letter from LP to LuValle January 16, 1941] [Filed under LP Correspondence: Box #218.11, file:(LuValle, James E.)]
- Writes cheque to "Mrs. E.T. Lewis," $12.50. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to “Mrs. E. T. Lewis. 100 lbs of soap” $12.50 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Writes cheque to “Arden. Milk, butter, eggs etc” $30.40 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Letter from Byron Higman, Kingswood School, England to LP RE: Sends LP extracts from his manuscripts concerning the “modern treatment of molecular structure” for comments by LP/ Notes he has been consulting LP's “The Nature of the Chemistry Bond” extensively during his research. [Letter from LP to Higman March 21, 1941] [Filed under LP Correspondence: Box #165.6, file:(H: Correspondence, 1941)]
- Letter from Stuart. R. Brinkley, Jr. to LP RE: states that Dr. Bryce Crawford has informed him that there are occasionally fellowships available for post-doctorate research. Would like to apply if any become available in the next year. [Reply from LP January 30, 1941] [Letter from Crawford to LP January 25, 1941] [Filed under LP Biographical: Academia: Box 1.017, Folder 17.3]
- Letter from W. Mansfield Clark, Johns Hopkins School of Medicine, to Dr. Frank B. Jewett, President, National Academy of Sciences. RE: Informs him that Harrison has been elected vice-president, and Mitchell and Fred have been elected councilors. Asks to know his opinion of their choice. [Filed under LP Science: National Academy of Sciences, 1939-1944: Box #14.018 Folder #18.2]
- Letter from W. Mansfield Clark, Johns Hopkins School of Medicine, to LP. RE: Informs him that E. B. Fred and S. A. Mitchell have been nominated as councilors. Informs him that Dr. Harrison has been nominated as vice-President. Is writing the President to for approval. [Filed under LP Science: National Academy of Sciences, 1939-1944: Box #14.018 Folder #18.2]
- Letter from Warren Weaver, The Rockefeller Foundation to LP RE: Weaver will be in Pasadena in February and hopes to discuss at length LP's proposal/request for aid for immunology experiments. [LP's letter January 2, 1941; LP's reply January 30, 1941] [Filed under LP Science: Rockefeller Foundation, 1936-1946: Box #14.038 Folder #38.9]
- Writes cheque to "Helms Bakeries," $5.80. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to “Helms Bakeries” $5.80 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Letter from L. A. Moyer, Executive Director and Chief Examiner, United States Civil Service Commission, to Head, Chemistry Dept, Cal Tech, RE: States they need metallurgical engineers who are not involved in essential industry work. Encloses information and applications. [Letter from LP to the United States Civil Service Commission January 28, 1941] [Filed under LP Correspondence: #421.3]
- Letter from unknown (unsigned) to John Rankin, RE: provides list of names.. [Filed under AHP: Federal Union, Pasadena Chapter: Box # 5.007, Folder 7.2]
- Research Notebook of LP, RNB 19R, p. 10 RE: Photochemical Explosion H2 + Cl2.
- Writes cheque to "H.G. Whipple," $50.00. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "Philharmonic Auditorium,' $25.30. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "Sanitary Laundry," $8.84. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to “Laundry. Sanitary Laundry” $8.84 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Writes cheque to “Whipple. My Teeth. $50.00 on account” $50.00 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Writes cheque “Ballet” $25.30 [LP Biographical: Business and Financial 4.072, folder 72.3]
- Letter from Jerome Alexander to LP RE: Asks him for a reprint of No. 783, which appeared in the Oct. 1940, number of the Journal of the Am. Chem. Soc. Once again requests an article on colloidal molecules for Alexander's new book. [Filed under LP Correspondence: Box #6.1, File:(Alexander, Jerome 1940-1954)]
- Letter from LP to Dr. James E. LuValle, Department of Chemistry, Fisk University, RE: Regrets to hear of the problems at Fisk. Notes that he will keep him in mind for position openings and is glad to serve as a reference. Suggests LuValle apply for a Civil Service appointment. Sends news from Cal Tech, noting that he is teaching freshman chemistry, Eyster is there as Hale Fellow, and that Schomaker is planning to go to Harvard on a Guggenheim Fellowship. [Notes from LuValle to LP January 11, 1941, February 13, 1941] [Filed under LP Correspondence: Box #218.11, file:(LuValle, James E.)]
- Letter from LP to Mr. A. A. Scullin, Technical and Reserach Div., The Texas Co., RE: Describes the relevant education and experience of Dr. L. R. Zumwalt, as well as his personality. [Letter from A.A. Scullin to LP January 10, 1941] [Filed under LP Correspondence: (S: Correspondence, 1941), #377.11]
- Letter from LP to Mr. Charles D. Russell, Dept. of Chemistry, Duke University, RE: States he is glad to Russell's reference, and expresses interest in Russell's current work. Encourages Russell to work on magnetic studies of sulfhemoglobin and catalase. [Letter from Mr. Charles D. Russell to LP January 11, 1941] [Filed under LP Correspondence: #340.6]
- Letter from LP to Prof. Arthur B. Lamb, Editor, JACS, RE: Thanks him for the report on Theorell's manuscripts and requests copies of the other manuscripts. [Letter from Lamb to LP January 20, 1941] [Filed under LP Correspondence: Box #191.1, file:(Journal of the American Chemical Society)]
- Letter from LP to the American Association of Petroleum Geologists, Inc. RE: Sends his recommendation that Dr. Roscoe Dickinson be inducted as associate member to the organization. [Filed under LP Correspondence Box: #94.5, file:(Dickinson, Roscoe G.: Correspondence, 1936-1941)]
- Letter from William Boyd to LP RE: Sends comments on LP's manuscript with Campbell and Pressman. Includes discussion on agglutination and clump formation in antibody-antigen reactions, as well as continued debate of the lattice theory versus the framework theory. Attached are some diagrams and a chart. (There are several notes in pencil by LP) [Letter from LP to Boyd January 9, 1941, January 29, 1941] [Filed under LP Correspondence: Box #29.3, file:(Boyd, William C., 1939-1945, 1956-1960)]
- Writes cheque to "Calif. Inst. Tech." $27.03. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "Willetts," $5.11. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to “Cit. Pewter” $27.03 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Writes cheque to “Willetts?. Peat Moss, bulb, etc” $5.11?” [LP Biographical: Business and Financial 4.072, folder 72.2]
- Approximate statement of the Rockefeller Budget [Filed under LP Science: Rockefeller Foundation, 1936-1946: Box #14.038 Folder #38.8]
- Letter from J.E. Mack, Department of Physics, University of Wisconsin, to LP RE: Requests he send reprint of LP's article on atomic scattering factors. (Note under text: “Acknowledge 1/21/41 JR”) [Filed under LP Correspondence: Box #255.8, file:(M: Correspondence, 1941)]
- Letter from T. K. Sherwood, National Defense Research Committee, to LP. RE: Thanks LP for his letter reporting on his progress. Sending information on hydrogen peroxide decomposition to the group studying engine performance with chemical fuels. [Letter from LP to Sherwood January 10, 1941, Letter from Chadwell to LP March 8, 1941] [Filed under LP Science: Scientific War Work - Materials re: the Pauling Oxygen Meter, 1940-1947: Box #13.001 Folder #1.1]
- Research Notebook of LP, RNB 19R, p. 11 RE: Equilibrium Fe+++ + 3 SCN-⇄ FeSCN++and Zeolite Water Softeneing.
- Letter from Prof. George Glockler, Department of Chemistry, State University of Iowa, to LP RE: Sends an application blanks and requests LP consider sending a student to do PhD work with him. [Letter from LP to Glockler January 25, 1941] [Filed under LP Correspondence: Box #136.15, file:(Glockler, George)]
- Letter from unknown (unsigned) to Bessie Little, RE: encloses an adherent card for Priscilla Beattle, membership renewal check from Annie J. Pitou, and Pasadena Star News and Pasadena Post bill. [Filed under AHP: Federal Union, Pasadena Chapter: Box # 5.006, Folder 6.5]
- Telegram from A.H. Compton to LP RE: Requests a confidential opinion of Warren Johnson's qualifications for a professorship at the University of Chicago. [Telegram from LP to Compton January 18, 1941] [Filed under LP Correspondence Box: #74.9, file:(C: Correspondence, 1940)]
- Telegram from LP to A.H. Compton RE: Replies that he considers Johnson one of the six best young in-organic chemists in the country. [Telegram from Compton to LP 12:24 p.m. January 18, 1941] [Filed under LP Correspondence Box: #74.9, file:(C: Correspondence, 1941)]
- Writes cheque to "Polytechnic Elementary School," $50.00. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to “Poly. On account” $50.00 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Letter from Arthur B. Lamb, Editor, JACS, to LP RE: Sends the two manuscripts by Dr. Fajans via airmail. Explains his doubts about the two papers. In a post-script mentions that he has written a “Notice to Authors” to appear in the January 1941 issue. (Notes in right margin: “No reason for preliminary pub.” “Contains nothing new [?] published by Fajans + discussed by many others.”) [Letters from LP to Lamb January 16, 1941, January 22, 1941] [Filed under LP Correspondence: Box #191.1, file:(Journal of the American Chemical Society)]
- Letter from F. B. Jewett, President, National Academy of Sciences, to Dr. W. Mansfield Clark, Johns Hopkins School of Medicine. RE: Raises a question about Harrison as vice-president, as he is heavily involved. [Filed under LP Science: National Academy of Sciences, 1939-1944: Box #14.018 Folder #18.2]
- Letter from H. I. Schlesinger, Dept. of Chemistry, University of Chicago, to LP RE: Discusses the details of the September symposium and the topic on which they would like LP to speak: “Resonance, Its Scope and Applicability to Organic Reactions.” Asks for a formal acceptance by LP. [Letters from LP to H. I. Schlesinger January 7, 1941, January 23, 1941] [Filed under LP Correspondence: #357.7]
- Letter from LP to Dr. Max Delbrück RE: Sends his responses to the Frank-Kamenetzky proposal. Regrets that he will be unable to attend the symposium on April 4 and 5. Adds that he has sent the reprint to Jordan. [Letter from Delbrück to LP January 7, 1941] [Filed under LP Correspondence Box: #92.1, file:(Delbrück, Max, 1940-1941)]
- Letter from LP to Dr. William Seifriz, Botanical Laboratory, University of Pennsylvania, RE: Agrees to help with the introduction but states he will be very busy. Mentions the work he is doing on Jerome Alexander's book and offers to send some of the useful information to Seifriz. [Note from William Seifriz to LP January 10, 1941, letter from William Seifriz to LP May 6, 1941] [Filed under LP Correspondence: #361.5]
- Permit from Courtenay Monsen, Secretary Pasadena Board of Education, to Mrs. Theodore Dunham, Jr., of Pasadena Chapter of Federal Union, RE: allows to use of McKinley Jr. High auditorium for meeting on January 28, 1941. [Filed under AHP: Federal Union, Pasadena Chapter: Box # 5.006, Folder 6.7]
- Writes cheque to "A.C. Vroman," $10.04. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "Farmer's Produce," $5.00. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "Mira Loma Mutual Water Co.," $2.72. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "Richfield Oil Co.," $9.88. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "William W. Taylor Jr." $8.45. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to “A. C. Vronam. Books” $10.04 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Writes cheque to “Dr Whipple. My teeth. Paid in full” $50.00 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Writes cheque to “H2O. Mira Loma H2O” $2.72 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Writes cheque to “Records - get money loan for W. C.” $0.77 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Writes cheque to “S. Cal. Ed. Co. Two mo” $26.40 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Writes cheque to “Wm. Taylor, clothes, etc” $8.45 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Letter from Dr. Karl Landsteiner, Rockefeller Institute for Medical Research, to LP RE: Sends comments and suggestions on LP's manuscript. Discusses his recent experiments with the S.A. immune sera in the context of LP's paper. [Filed under LP Correspondence: Box #212.7, file:(Landsteiner, Ernest Karl)]
- Letter from LP to Mr. Edward C. Barrett RE: Informs that Miss Edris Roseland (Mrs. Jack Rauchfuss) resigned her position as Office Assistant in Gates and Crellin Laboratories of Chemistry on January 9. Requests a check be issued to her covering January 2 to 9. [Filed under LP Biographical: Academia: Box #1.029 file 29.1]
- Writes cheque to "F.C. Nash," $20.09. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "Standard Oil Co. of Calif." $3.35. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to S. Counties Gas Co.," $5.14. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to “F. C. Nash. Presents” $20.09 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Writes cheque to “Richfield Oil Co. Gasoline” $9.88 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Writes cheque to “S. C. Gas Co. Gas” $5.14 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Writes cheque to “Standard Oil Co.” $3.35 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Federal Union Inc. Headquarters Bulletin No 10. Dinner at the Waldorf-Astoria. [Filed under Publications re: Union Now/Federal Union, Inc., 1940-1941: Box # 5.009, Folder 9.6]
- Letter from Jack M. Tien to LP RE: inquires about available fellowships or assistantships in the department. [Reply from LP January 30, 1941] [Filed under LP Biographical: Academia: Box 1.017, Folder 17.3]
- Letter from LP to Arthur B. Lamb, Editor, JACS, RE: Recommends the communication to the editor by Dr. Brown be published. Comments on the communications by Fajans and recommends that they not be published. [Letter from Lamb to LP January 20, 1941] [Filed under LP Correspondence: Box #191.1, file:(Journal of the American Chemical Society)]
- Letter from W. Mansfield Clark, Johns Hopkins School of Medicine, to LP. RE: Encloses a copy of President Jewett's letter. Informs them of their votes. Asks for a vote between the names mentioned. [Filed under LP Science: National Academy of Sciences, 1939-1944: Box #14.018 Folder #18.2]
- Research Notebook of LP, RNB 19R, p. 12 RE: Amphoteric Hydroxide.
- Writes cheque to "S. Calif. Tel. Co.," $11.90. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "Taylor's Market," $5.00. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to “Telep. S. Calif. Tel Co. 2 months” $11.90 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Letter from Dr. Arthur Cope to LP RE: Informs him that he has written Dr. Marvel about Maurice Schlatter. Thanks LP for his pleasant stay at Cal Tech. [Letter from LP to Cope January 28, 1941] [Filed under LP Correspondence: Box #67.3, file:(Cope, Arthur C., 1940-1941, 1954, 1958, 1964)]
- Letter from LP to Arthur B. Lamb, Editor, JACS, RE: Comments on the communication by Dr. Redlick, which he approves of for publication. [Filed under LP Correspondence: Box #191.1, file:(Journal of the American Chemical Society)]
- Letter from LP to Arthur B. Lamb, Editor, JACS, RE: Submits for publication a manuscript by Giguere and Rundle entitled “The Vapor Density of Hydrazine.” [Filed under LP Correspondence: Box #191.1, file:(Journal of the American Chemical Society)]
- Letter from LP to Dr. A. M. Pappenheimer, Jr., Department of Bacteriology, University of Pennsylvania. [Letters from Pappenheimer to LP November 5, 1940, January 10, 1941] [Filed under LP Correspondence: Box #312.6, file:(P: Correspondence, 1941)]
January 23, 1941
Dr. A. M. Pappenheimer, Jr.
Department of Bacteriology
University of Pennsylvania
Philadelphia, Pennsylvania
Dear Dr. Pappenheimer:
I am very sorry to have been so dilatory about replying to your letter. It was a surprise to me to see that two months had gone by since it reached me—the period has been so busy that I have not noticed how long I was delaying. I was very much interested to read your reprints and your manuscript with Dr. Petermann. I am returning the manuscript under separate cover.
Some of the assumptions in my paper on the structure of antibodies were made for the sake of simplicity. Thus I can not contend that antibodies are necessarily elongated with their active groups at the extreme ends. The evidence which you have obtained shows that this assumption is not always right. Also if the antibodies aggregate the effective valence may be increased, as you suggest. It is not indeed required that the valence of the primary antibody molecule be restricted to 2, but it seems likely to me that most antibodies have the valence 2 because the process of antibody manufacture becomes more complex as the valence increases.
My theory does not require that the active part of an antibody be less stable than other parts. It does, I think, require that the stability of antibodies analogous to different antigens be in general different.
The situation regarding antigen activity in relation to strength of groups is not at all clear. I am not sure that the argument which I presented is sound, and nearly every immunologist with whom I have talked has found fault with my conclusion.
It would be very interesting indeed to know through experiment whether your enzyme treated antitoxin has or has not a higher proline content than the original untreated antitoxin.
Drs. Dan Campbell and David Pressman and I have been carrying on some experiments during the last few months. We have obtained precipitates with various simple substances containing two or more atoxyl groups and antitoxyl serum, verifying Landsteiner and van der Scheer's results, and we have got evidence that our dye solutions are not colloidal by observing their dialysis through cellophane.
I hope that I shall be able to talk with you some time. I shall try to visit the University of Pennsylvania on some eastern trip, and I hope that whenever the opportunity presents itself you will make a visit to our Laboratories.
Sincerely yours,
Linus Pauling
LP:jr
Air Mail
- Letter from LP to Dr. H. I. Schlesinger, Dept. of Chemistry, University of Chicago, RE: Accepts the invitation to speak at the symposium in September and states he will be visiting Chicago at the beginning of February. [Letters from H. I. Schlesinger to LP January 20, 1941, January 27, 1941] [Filed under LP Correspondence: #357.7]
- Letter from LP to Dr. W. Mansfield Clark, Johns Mansfield School of Medicine. RE: Votes for Bowman for vice-president. [Filed under LP Science: National Academy of Sciences, 1939-1944: Box #14.018 Folder #18.2]
- Note from Dr. Oliver Wulf to LP RE: Informs him that the reprints of their two infrared articles were not purchased due to lack of funds, but they personally purchased a few copies which he is glad to send on. Asks LP to share it with their collaborators, adds observations about his current studies on the atmosphere and its behavior. [Letter from LP to Wulf January 28, 1941] [Filed under LP Correspondence: 443.9]
- Note from Norman E. Schneider to Gentlemen, Caltech, RE: Inquires about a formula or process for tinning on copper and brass, to be used on cooking tools. [Letter from Secretary, Chemistry Division, to Mr. Norman E. Schneider January 28, 1941] [Filed under LP Correspondence: (S: Correspondence, 1941), #377.11]
- Freshman Chemistry Quiz (25 minutes) closed book and notes. [Filed under LP Biographical: Academia: Box 1.012, Folder 12.6]
- Letter from Hugh S. Taylor, Frick Chemical Laboratory, Princeton University, to LP RE: Recommends Mr. J. W. Sease as a graduate student who might fit the needs of Cal Tech. Asks for Cal Tech to recommend a graduate student to Princeton “so that we might have an additional measuring stick with which to grade our own products.” [Letters from LP to Hugh S. Taylor December 7, 1940, January 30, 1941] [Filed under LP Correspondence: #405.6]
- Letter from LP to Mr. Edward C. Barrett RE: Recommends Mr. Norman Abrahamsen be appointed Research Assistant to Dr. Koepfli until June 30, 1941 to be paid $100 per month from the General Chemistry fund. [Filed under LP Biographical: Academia: Box #1.029 file 29.1]
- Memorandum from Henry Allen Moe, Secretary, to members of the Committee of Selection. RE: Reminds them of the first meeting of the Committee. [Filed under LP Science: John Simon Guggenheim Memorial Foundation, 1925-1945: Box #14.013 Folder #13.7]
- Letter from B. L. Crawford, Jr., School of Chemistry, University of Minnesota RE: discusses the work and character of Stuart R. Brinkley, Jr. and hopes that LP can find a position for him at Caltech that does not involve experimental work. [Letter from Brinkley to LP January 13, 1941] [Reply from LP January 30, 1941] [Filed under LP Biographical: Academia: Box 1.017, Folder 17.3]
- Letter from LP to Dr. Frank H. Spedding, Dept. of Chemistry, Iowa State College, RE: Thanks Spedding for the letter about Mr. Sayre. [Filed under LP Correspondence: #367.3]
- Letter from LP to Prof. George Glockler, Department of Chemistry, State University of Iowa, RE: Informs him that his top graduating students this year are two American-born Japanese. Asks if Glockler would be willing to give a fellowship to one of them. Notes that Latimer at Berkeley also recently sent a student of Japanese ancestry to the Midwest. [Letters from Glockler to LP January 18, 1941, January 28, 1941] [Filed under LP Correspondence: Box #136.15, file:(Glockler, George)]
- Letter from Thomas K. Sherwood, Technical Aide, Division B, National Defense Research Committee, to LP. RE: Is getting into a problem of masks and oxygen breathing equipment for aviators. Asks if LP could produce 3-4 of his instruments for this use. [Telegram from Sturdivant to Sherwood, January 30, 1941] [Filed under LP Science: Scientific War Work - Materials re: the Pauling Oxygen Meter, 1940-1947: Box #13.001 Folder #1.2]
- Letter from unknown (unsigned) to Bessie Little, RE: encloses an adherent card for Margaret E. Brown. [Filed under AHP: Federal Union, Pasadena Chapter: Box # 5.006, Folder 6.5]
- Writes cheque to "Mr. Paul Strand," $15.00. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Approximate statement of the Rockefeller Budget [Filed under LP Science: Rockefeller Foundation, 1936-1946: Box #14.038 Folder #38.8]
- Writes cheque to “Paul Stand. 48 Grove St. N.Y. Mexican book” $15.00 [LP Biographical: Business and Financial 4.072, folder 72.2]
- Letter from H. I. Schlesinger, Dept. of Chemistry, University of Chicago, to LP RE: Thanks LP for accepting the invitation to speak at the symposium and mentions the other speakers as well as other programs throughout the week. [Letters from LP to Dr. H. I. Schlesinger January 23, 1941, from H. I. Schlesinger to LP April 14, 1941] [Filed under LP Correspondence: #357.7]
- Copy of letter from W.F. Coover to LP RE: Informs him that the Chemistry Department at Iowa State College plans to hire an assistant professor. Asks LP to recommend potential candidates, and give his opinion of a Dr. Palmer. (Notes in left margin: “Randle, Palmer, Randle - carbohydrate chem. at Nebraska, Bear”) [Letter from LP to Coover February 14, 1941] [Filed under LP Correspondence Box: #304.3, file:(Palmer, Kenneth J.)]
- Letter from Dr. Henry Eyring, Department of Chemistry, Princeton, to LP RE: Recommends to him Dr. Purdandu Nath Chakravorty, a PhD from India who has been at Windaus's lab in Heidelburg and is looking for work in the U.S. [Letter from LP to Eyring February 8, 1941] [Filed under LP Correspondence: Box #110.8, file:(Eyering, Henry, 1935-1936, 1939, 1941, 1949, 1964-1966)]
- Letter from George B. Moffat, Head of Office of Pasadena Chapter of Federal Union, to all office workers, RE: suggests when not completing another tasks to write letters to others, especially those of high public or social status, advocating Federal Union. [Filed under AHP: Federal Union, Pasadena Chapter: Box # 5.006, Folder 6.3]
- Letter from HJ Lucas to Mr. Edward C. Barrett RE: Outlines an accident that happened in the lab the previous day when a flask holding material exploded. Mr. Clark Gould was taken to the hospital and is feeling alright. [Filed under LP Biographical: Academia: Box #1.029 file 29.1]
- Letter from LP to Dr. Albert Schoenflies RE: States that they can find support for Schoenflies' three sons in California if they can find a way to get them from Holland to the U.S. [Letters from Albert Schoenflies to LP October 21, 1940, March 15, 1941] [Filed under LP Correspondence: #358.1]
- Letter from LP to Dr. Arthur Cope RE: Thanks him for writing Dr. Marvel about Schlatter. [Letter from Cope to LP January 23, 1941] [Filed under LP Correspondence: Box #67.3, file:(Cope, Arthur C., 1940-1941, 1954, 1958, 1964)]
- Letter from LP to Dr. Henry Allen Moe, John Simon Guggenheim Memorial Foundation. RE: Informs him of his arrival time on February 2nd. [Filed under LP Science: John Simon Guggenheim Memorial Foundation, 1925-1945: Box #14.013 Folder #13.7]
- Letter from LP to Dr. Oliver Wulf RE: Replies that he will put the reprints to use and comments that he had not noticed the interesting discoveries about the atmosphere Wulf is studying and wishes that they were closer so he could learn about these things directly. [Letter from Wulf to LP January 23, 1941] [Filed under LP Correspondence: 443.9]
- Letter from LP to Dr. Roger Adams RE: Recommendation letter for Maurice Schlatter to a post-doctoral appointment at the University of Illinois. Mentions Schlatter's work under Prof. Lucas and Dr. E. R. Buchman. [Filed under LP Correspondence: Box #1.3, file:(Adams, Roger)]
- Letter from LP to the United States Civil Service Commission RE: States that announcement by the Commission has been placed on bulletin boards. [Letter from L. A. Moyer, Executive Director and Chief Examiner, United States Civil Service Commission January 15, 1941] [Filed under LP Correspondence: #421.3]
- Letter from Prof. George Glockler, Department of Chemistry, State University of Iowa, to LP RE: Notes that he has already sent one application to Ikeda and will another for Ikawa. Regrets that neither are interested in physical chemistry. Adds that they “will consider their qualifications irrespective of race.” [Letters from LP to Glockler January 25, 1941, February 8, 1941] [Filed under LP Correspondence: Box #136.15, file:(Glockler, George)]
- Letter from Secretary, Chemistry Div., Caltech, to Mr. Norman E. Schneider RE: Writes: “I regret that we haven't any special information for Tinning on copper and brass.” [Note from Norman E. Schneider to Gentlemen, CatTech, January 23, 1941] [Filed under LP Correspondence: (S: Correspondence, 1941), #377.11]
- Letter from W. F. Coover, Dept. of Chemistry, Iowa State College, RE: Describes a position they have opening for an assistant professorship and asks if LP has any recommendations for candidates. [Letter from LP to Dr. W. F. Coover February 14, 1941] [Filed under LP Correspondence: #336.12]
- Letter from W.F. Coover to LP RE: Informs him that the Chemistry Department at Iowa State College plans to hire an assistant professor. Asks LP to recommend potential candidates, and give his opinion of a Dr. Palmer. (Notes in left margin: “Randle, Palmer, Randle - carbohydrate chem. at Nebraska, Bear”) [Letter from LP to Coover February 14, 1941] [Filed under LP Correspondence Box: #74.9, file:(C: Correspondence, 1941)]
- Postcard from G. Lewiston, U.S. Department of Agriculture, Bureau of Dairy Industry, to LP RE: Requests a reprint of “The Structure of Proteins” by LP and Carl Niemann. (Note under text: “Sent 2/13/41 JR.” [Filed under LP Correspondence: Box #230.7, file:(L: Correspondence, 1941)]
- Writes cheque to "Department of Motor Vehicles," $16.00. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to “Dept. Motor Vehicles. Ford. $3.90 Zephyr $12.10" $16.00 [LP Biographical: Business and Financial 4.072, folder 72.3]
- Letter from JHS to LP RE: Attached summary of expenditures on the Instrument Supplies and Equipment accounts for the Rockefeller Budget [Filed under LP Science: Rockefeller Foundation, 1936-1946: Box #14.038 Folder #38.8]
- Letter from LP to L.A. Kimpton, Dean, Deep Springs, RE: Recommends Ralph Spitzer for the position at Deep Springs. Notes that he is looking for a less strenuous job for next year due to eye troubles and is willing to drive to Deep Springs for an interview. [Letters from Kimpton to LP December 26, 1940, February 5, 1941] [Filed under LP Correspondence: Box #198.9, file:(Kimpton, L. A.)]
- Letter from LP to Mr. R. W. Stenzel, Petroleum Rectifying Company of California, RE: States he will be out of town until Thursday, February 6, but could meet with Stenzel on Thursday afternoon. [Letter from R. W. Stenzel to LP January 1941] [Filed under LP Correspondence: (S: Correspondence, 1941), #377.11]
- Letter from LP to William Boyd. [Letter from Boyd to LP January 16, 1941] [Filed under LP Correspondence: Box #29.3, file:(Boyd, William C., 1939-1945, 1956-1960)]
January 29, 1941
Professor William C. Boyd
Department of Biochemistry
Boston University
School of Medicine
80 E. Concord Street
Boston, Massachusetts
Dear Dr Boyd:
I am very glad to have your comments on our paper. We are changing the wording in just the way that you recommend. It was, of course, wrong for me to write that you failed to verify Landsteiner's observations. Dr. Landsteiner has also written to me that this sentence is incorrect.
I am having Dr. Pressman send some samples of our precipitable haptens to you.
I am afraid that, because of ionization, it would be difficult to obtain freezing point or boiling point evidence regarding the molecular state of our dyes. We have, however, shown that most of the dyes with which we worked pass easily through a cellophane membrane, and that the precipitin reaction can be obtained with material which has just passed through the membrane. The pores in the membrane are perhaps about 30 Å in diameter. It is, of course, possible that the dye polymerizes, and exists in equilibrium with the unpolymerized molecules, which again polymerize after passing through the membrane. Nevertheless the ease of dialysis of the dye suggests that they are not largely colloidal.
I was not suggesting in my letter that you did not publish your observations but rather that your published observations might be interpreted as evidence for the framework theory of agglutination. The first and third paragraphs on page 349 of your 1937 paper on mixed agglutination say that under some conditions separate agglutination of the cells of different types occur and that heterogeneous clumps were obtained only under definite conditions. If the second phase of flocculation were not specific, we might well expect heterogeneous clumps under all conditions, and interpret your observations as evidence against this postulate.
Sincerely yours,
[Linus Pauling]
LP: jr
- Postcard from Seymour H. Wollman, Physics Department, Duke University to LP RE: Requests reprint of “A Quantum Mechanical Discussion of Substituents in Aromatic Molecules.” (Note under text in pencil: “Sent 2/[3]/41 JR”) [Filed under LP Correspondence: 443.9]
- Budget estimates [Filed under LP Science: Rockefeller Foundation, 1936-1946: Box #14.038 Folder #38.8]
- Confidential report by LP to the Departments of Chemistry, Columbia University and the University of California RE: Discusses Homer Jacobson, a gifted and precocious student in Chemistry at Cal Tech who will receive his degree at 18 and will plan to pursue graduate studies. [Filed under LP Correspondence: Box #192.8, file:(J: Correspondence, 1941)]
- Letter from Dr. R. Bowling Barnes to LP RE: Introduces to him Dr. Richard Roblin and four others who are planning a trip to Cal Tech. [Letter from LP to Barnes February 20, 1941] [Filed under LP Correspondence: Box #37.8, file:(B: Correspondence, 1941)]
- Letter from LP to AHP. [Filed under LP Safe: Box #1.015, Folder #15.1]
Thursday, 6 PM
Dearest little wife:
I had forgotten how lonesome it is possible to feel in one minute- I think that the lonesomest time of the whole trip is the first minute of parting, when I realize that the whole next week is to be away from you- although perhaps the last day on the way home is worse. I hope that this trip will go by fast.
I was sorry to see that Crelly was frightened by the train. I had forgotten that he had not seen many.
As we left the station I looked up at our beautiful foothill slope and tried to find our house, where we all live so happily together, and I thought about you- what a beautiful and good girl you are, how much I love you, how happy I am to have you for my little wife, what fine children you have borne, how wisely you are rearing them- and I promised myself that I would tell you these things when I see you again. I like to think about falling in love with you, and about all the years of being in love with you that have gone by.
This afternoon I have read- applications, Spurr's article, the Saturday Evening Post- sitting in my Pullman seat. Only now have I come back to the observation car to write to you, at the little writing table. I notice now (as on the last trip) that I have begun to feel carsick- I think that it may be due to my bending over the table while writing.
The mountains and desert have been beautiful- the bog rocks on the way up to Cajon Pass, the snow-covered San Bernardinos, the Joshua trees near Victorville, the Calicos. Now it is dark.
Give my love to the children, dear little wife.
Much love from you
Linus
- Letter from LP to AHP. [Filed under LP Safe: Box #1.015, Folder #15.2]
Thursday 8 P.M. [January 30]
Dearest Paddy:
I have just finished my work - supper - dishes - and a great lot of oat meal cookies. If you were here I might let you have one. I’ve decided to send some to James. He likes them so well and it is a shame that he should have them only once a year. Little Crellie and I watched your train sail on out of sight then we drove home via New Oak [?] Avenue. I purchased a flat of verbena, too, and they are already in the ground. Linus is at a He Y [?] meeting. He said he didn’t want to go but that he had to go. I said “Nonsense.” Also that I wouldn’t come and get him since I’m tired. I think I won’t go. He wanted to stay overnight tomorrow night too, with the little [?] girl, I mean, but I said he couldn’t that I would get him at eleven o’clock. He is a scheme all right and clever, too.
How are you? Dr Edsall called and invited me to their house tomorrow evening to meet some English people whom they met in Berkeley. I don’t want to go very much but will go first for a little while to the folk dancing and then for a short while to the Edsalls’. Isn’t it odd that he called? This afternoon I called on the Tylers with Crellie and Linda while we waited for Peter. She was happy to see us and they have a charming little house and garden. It is too bad she hasn’t some of Lena Weinbaums [sic] excess artistic talent. Say do you realize you didn’t give me your address in New York? How can I write to you? Such a fellow! How is the little Paddy? You are a big joke. A man called to ask if our property here for sale. I said “No.”
I suppose you think you are pretty smart don’t you. Guggenheim Advisory Board. Fui! [sic] They ought to know who the Paddy Advisory Board is. I’m going to read the paper in bed and I won’t be bothered by any pestiferous Paddy either.
Love to you, Member of the Selection Board of the John Simon Guggenheim Memorial Foundation — to say nothing about the Advisory Board. Ava Helen Pauling
[Filed as 1941x.01.30.AHP]
- Letter from LP to Dr. Anton Burg, Department of Chemistry, University of Southern California RE: writes that Mr. Robert Anton Spurr said he would very much like to have the job with Burg, he is interested in teaching quantitative analysis and continuing his structural research. Recommends Spurr very strongly. [Filed under LP Biographical: Academia: Box 1.018, Folder 18.2]
- Letter from LP to Dr. Bryce L. Crawford, Jr., School of Chemistry, University of Minnesota RE: replies to letter about Brinkley. LP had forgotten about accident. He does not think there is much chance for an appointment, but he will do what he can. [Letter from Crawford to LP January 25, 1941] [Filed under LP Biographical: Academia: Box 1.017, Folder 17.3]
- Letter from LP to Jerome Alexander RE: Responds that he is very busy this winter and will not be able to prepare a paper unless there is delay in publication of the manuscript. Encloses a copy of the reprint requested. [Letter from Alexander to LP January 16, 1941] [Filed under LP Correspondence: Box #6.1, file:(Alexander, Jerome, 1940-1954)]
- Letter from LP to Mr. Jack M. Tien RE: informs that it is improbable that any new appointments will be made this year. [Letter from Tien to LP January 22, 1941] [Filed under LP Biographical: Academia: Box 1.017, Folder 17.3]
- Letter from LP to Mr. Stuart R. Brinkley, Jr., Sterling Chemistry Laboratory RE: Informs that it is improbable that any new appointments will be made but suggests that Brinkley send a letter describing his research interests. [Letters from Brinkley to LP January 13, 1941, February 17, 1941] [Letter from Crawford to LP January 25, 1940] [Filed under LP Biographical: Academia: Box 1.017, Folder 17.3]
- Letter from LP to Prof. Hugh S. Taylor, Dept of Chemistry, Princeton University, RE: Thanks Taylor for the letter regard J. W. Sease. Apologizes and explains why Cal Tech sends so few chemistry graduate students to other institutions. Recommends and describes the merits of two upcoming graduate students: Miyoshi Ikawa and John Mead Richardson. [Letter from Prof. Hugh S. Taylor to LP January 24, 1941] [Filed under LP Correspondence: #405.6]
- Letter from LP to Prof. P.A. Leighton, Department of Chemistry, Stanford University, RE: Introduces to him Robert S. Rasmussen, a PhD candidate in chemistry at Cal Tech who is looking for an academic appointment. [Filed under LP Correspondence: Box #230.7, file:(L: Correspondence, 1941)]
- Letter from LP to Prof. Thorfin Hogness, Department of Chemistry, University of Chicago, RE: Writes that he will arrive in Chicago at 8:30 on Tuesday morning to stopover on his way to the Guggenheim meeting in New York. Tells Hogness not to meet him at the station; he will find his way to the university. Asks if Rasmussen could be given an appointment in Hogness' department next year. [Filed under LP Correspondence: Box #162.5, file:(Hogness, Thorfin)]
- Letter from W. Mansfield Clark, Johns Hopkins School of Medicine, to LP. RE: Informs him of the vote for vice-president. Will write to Jewett informing him of their choice of Bowman. [Filed under LP Science: National Academy of Sciences, 1939-1944: Box #14.018 Folder #18.2]
- Telegram from James H. Sturdivant to Thomas K. Sherwood, National Defense Research Committee. RE: Is forward his letter on to LP in New York. Will suggest he offer delivery in four weeks. [Letter from Sherwood to LP January 25, 1941, Telegram from LP to Sturdivant February 2, 1941] [Filed under LP Science: Scientific War Work - Materials re: the Pauling Oxygen Meter, 1940-1947: Box #13.001 Folder #1.2]
- Writes cheque to "Dr. H.G. Whipple," $50.00. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "S. California Edison Co.," $26.40. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "Santa Fe," $135.00. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "Santa Fe," $66.75. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Writes cheque to "The Music Shop," $0.77. [Filed under LP Biographical: Business and Financial, Box 4.016, Folder 16.1]
- Letter from A. N. Kemp, President, Lincoln Club, to LP RE: Informs LP that he has been elected to membership in the club. Invites him to their annual meeting in honor of Lincoln's birthday on February 12. Also informs him of the necessary dues to be paid upon acceptance of membership. [Letter from LP to Kemp February 11, 1941] [Filed under LP Correspondence: Box #230.7, file:(L: Correspondence, 1941)]
- Letter from Dr. Denis L. Fox, The Scripps Institution of Oceanography, University of California, to LP RE: Informs LP that he is looking for a research assistant for the labs for the period of a year. Includes information relevant to benefits and expected fields of research. Requests LP recommend a candidate. Mentions Dr. Zechmeister's visit earlier in the month. (Note in left margin: “Jacobson”) [Letter from LP to Fox February 14, 1941] [Filed under LP Correspondence: Box #120.10, file:(Fox, Denis L.)]
- Letter from Prof. J. Murray Luck, Department of Chemistry, Stanford University, to LP RE: Invites LP to a chemistry conference to be held at Stanford the week of June 23, 1941. [Letter from LP to Luck February 8, 1941] [Filed under LP Correspondence: Box #230.7, file:(L: Correspondence, 1941)]
- Letter from Roger Stanton, President Students Fund, Inc to LP RE: Requests donation to contribute to the scholarship fund in order to make new loans to students. [Note on bottom: $10.00 sent 2/6/41] [Filed under California Institute of Technology: Materials re: Division of Chemistry and Chemical Engineering, 1933-1963, No Date: Box #1.024, Folder 24.9]
- Letter from unknown (unsigned) to Bessie Little, RE: encloses membership card and check and gives updates on membership status of several listed people. [Filed under AHP: Federal Union, Pasadena Chapter: Box # 5.006, Folder 6.5]
- Postcard from W.W. Hoskins, Division of Entomology and Parasitology, UC Berkeley, to LP RE: Requests reprint. (Note in top right: “Sent 2/13/41 JR”) [Filed under LP Correspondence: Box #165.6, file:(H: Correspondence, 1941)]
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