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"The Origins of Molecular Biology and Molecular Medicine." May 20, 1986.
Recording of a Pauling lecture. Produced by Medical Television, University of Alabama, Birmingham.
Working on Proteins with Alfred Mirsky. (1:22)
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Linus Pauling: So I became interested in proteins. In 1936 we published this material. That year also I asked Alfred Mirsky to come from
the Rockefeller Institute to Pasadena for a couple of years, in fact. He taught me how to handle proteins, how to purify hemoglobin
and things of that sort. He and I published a paper in 1936 on a theory of native and denatured proteins, which is, I think,
pretty much the accepted theory - that the native protein is folded in a well-defined way. This native protein molecule, such
as this one [slide], stabilized by various interactions including hydrogen bonds. And that denaturing agents or conditions
caused polypeptide chains to unfold and they can get tangled up with one another and an insoluble coagulum can form. The denatured
protein, the specific properties, tend to be lost. So I thought an interesting problem would be to find how the polypeptide
chains are folded in proteins.
ClipCreator: Linus Pauling
Associated: Alfred E. Mirsky
Clip ID: 1986v.9-proteins
Full WorkCreator: Linus Pauling
Associated: University of Alabama at Birmingham
Date: May 20, 1986
Copyright: More Information