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"The Origins of Molecular Biology and Molecular Medicine." May 20, 1986.
Recording of a Pauling lecture. Produced by Medical Television, University of Alabama, Birmingham.
Working with Karl Landsteiner on Immunochemistry. (1:43)
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Linus Pauling: Well, I gave a lecture, Grand Rounds, at Rockefeller Institute for Medical Research in 1936. One of the people in my lecture
was Karl Landsteiner. He had discovered the blood groups in 1900. He asked if I would come to his laboratory to talk with
him, which I did. And later, when I was lecturing at Cornell, he came up to Cornell, to Ithaca, for a week, and gave me an
intensive course - one of the best courses probably anyone ever got - in immunology, immunochemistry. So he asked if I could
explain his observations on direction of apoproteins with analogous antiserum. And I didn't know anything about immunology
and couldn't explain. But I began thinking and after four years, formulated my ideas. There were, at that time, two general
ideas about how biological substances can show specificity - enzymes, antibodies, the gene producing replicates of itself
and so on. One is the idea that in some way, the molecule produces a replicate of itself. The other idea about biological
specificity was the lock and key idea. In 1940, I published a paper on the structure of antibodies and the nature of serological
ClipCreator: Linus Pauling
Associated: Karl Landsteiner
Clip ID: 1986v.9-landsteiner
Full WorkCreator: Linus Pauling
Associated: University of Alabama at Birmingham
Date: May 20, 1986
Copyright: More Information