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Letter from S. J. Singer to Linus Pauling. March 12, 1958.
Singer writes to update Pauling on the details of new research that he and Harvey Itano have undertaken on the properties of A, S, and C hemoglobins. Singer also notes his group's excitement at "the density gradient sedimentation studies," and briefly mentions a pleasant visit with Frank Stahl.

Transcript

DEPARTMENT OF CHEMISTRY

YALE UNIVERSITY NEW HAVEN,

CONNECTICUT

STERLING CHEMISTRY LABORATORY 225

PROSPECT STREET

12 March 1958

Dr. Linus Pauling

Department of Chemistry

California Institute of Technology

Pasadena 4, California

Dear Linus:

Harvey Itano and I have been collaborating recently on some further studies with normal and sickle hemoglobins, concerning their dissociation and association in acid solutions. We find that mixtures of A, S, and C hemoglobins, dissociated and then re-associated, form no electrophoretically distinct hybrids. We thought that you would be interested in these results and are enclosing a manuscript which we are about to submit to Proc. Nat. Acad. Sci. [handwritten: "to WAS 2/31/58"]

Both Harvey and I are planning to attend the San Francisco A.C.S. meeting next month, and Ruth and I hope to spend a little time with her folks in Sierra Madre before the meeting. I will drop in then and visit.

We are all very excited by the density gradient sedimentation studies, which are certainly beautiful. Frank Stahl visited Yale a few weeks ago, and we had a stimulating time.

With best regards, and looking forward to seeing you

Sincerely,

S. J. Singer

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